I am sure you have heard about mesotherapy as a popular treatment in Europe. Injection of mesotherapy solutions is not FDA approved in the US but you may use the mesotherapy solutions with micro needling to penetrate under the skin. Mesotherapy is intra-dermal injection of any medication. It started in 1950s and recently became very popular in Europe. Mesotherapy is a minimally invasive technique that consists of LIT with pharmaceuticals or other bioactive substances given in small quantities through dermal multi-punctures

It is shown to be effective in the treatment of painful, loco-regional conditions. They also emphasized that the clinical efficacy of LIT has been demonstrated in the management of chronic venous lymphatic insufficiency, oedematous fibrosclerotic panniculopathy and facial skin aging.

In 2011 the European review of medical and pharmaceutical Sciences published a consensus :Mesotherapy, definition, rationale and clinical role: a consensus report from the Italian Society of Mesotherapy. Italy and France are the most advanced countries in term of making mesotherapy solutions.

The term “mesotherapy” comes from the Greek word “mesos” referring to the mesoderm (or middle germ cell layer) in the early embryo which differentiates into tissues and structures, including bone, cartilage, muscle and connective tissue including skin and subcutaneous tissue.

Over a century ago, the first mesotherapy started as intraodermal injection of active ingredient of a medication mixed with procaine/Novocaine.

Mesotherapy is effective in the treatment of painful musculoskeletal conditions, chronic venous lymphatic insufficiency (CVLI), oedematous fibrosclerotic panniculopathy (OFP, more commonly known as cellulite), intradermal vaccination, and in the management of facial skin aging.