UNIVERSAL: ANY TYPE OF CO2 SOURCE
CARBOXY-PEN®
THE LATEST TECHNOLOGY FOR CARBOXYTHERAPY
Carboxytherapy : History
1932 ROYAT
Administration of CO2
- Varicous ulcers
- Arterial gangrenes
1983 ROYAT
400,000 patients treated
2001, 2004 University of SIENNE
Dr Brandi
- Tensor effect by Carboxytherapy [2]
- Study about adipolysis by C02 [1]
1953
Dr Jean Baptiste Romuef
Publication about 20 years of treatment
1992
Dr Jérome Berthier Cellulite treatment
Currently
20,000 patients / year
[1] Brandi C, D’Aniello C, Grimaldi L, Bosi B, Dei I, Lattarulo P, Alessandrini C. Carbon dioxide therapy in the treatment of localized adiposities: clinical study and histopathological correlations. Aesthetic Plast Surg. 2001 May-Jun;25(3):170-4.
[2] Brandi C, D’Aniello C, Grimaldi L, Caiazzo E, Stanghellini E. Carbon dioxide therapy: effects on skin irregularity and its use as a complement to liposuction. Aesthetic Plast Surg. 2004 Jul-Aug;28(4):222-5
CARBOXY-PEN: A world reference for Carboxytherapy
20 years of development in compliance with medical demands
Whole control
- The depth
- The speed
- The angle
- The volume
Total control
Painless effect
Simultaneous massage
Main Carboxytherapy indications
- Cellulite
- Stretch marks
- Wrinkles
- Skin & muscular laxity
- Dark circles
- Localized adiposities
- Periorbital areas
- Vaginal rejuvenation
And many more…
- Raynaud syndrome,
- acute arthritis, ulcer,
- pre and post graft skin…
Carboxytherapy : Processus generated
Decrease of veins disorders
Improvement of the skin elasticity
PHYSIOLOGICAL PRINCIPLES:
- Activation of the microcirculatory vasodilatation
- Increase the microcirculation
- Increase the lipolytic action of the localized adiposities
- Increase the oxygen level in superficial areas
Carboxytherapy : Technical informations
Oxyhemoglobin dissociation curve
Bohr effect (1904): Improvement of the oxygen level in the skin by injection of CO2
CO2 + H2O -> H2CO3 -> H+ + HCO3-
Excess of CO2 reacts with water to form carbonic acid
Carbonic acid is dissociated in bicarbonate ion & H+ ion
CO2 induces a decrease of pH by a release of H+ ions and hypercapnia
Right shift of the oxyhemoglobin dissociation curve induces O2 release in the tissue.
Carboxytherapy : All areas
Poor blood and lymphatic microcirculation
Better blood and lymphatic circulation
- Face
- Eyes
- Dark Circles
- Body
- Legs
- Abdomen
CO2 induces O2 release in the tissue
Wrinkles protocol
Several injections in wrinkles
6 – 8 sessions for a complete treatment
P R O T O C O L c o m b i n a t i o n
Needle
Injection
Use 30 G – 32 G
2 cc / point
Depth
Frequency
From 1 to 3 mm
2 sessions / week
Skin laxity improvement
Reoxygenate the treatment area
Increase blook’s circulation
Generate the firming up of muscles
Injection all over the treatment area 4 – 6 sessions for a complete treatment
P R O T O C O L c o m b i n a t i o n
Needle
Injection
Use 30 G – 32 G
2 - 4 cc / point
Depth
Frequency
From 1 to 2 mm
1 or 2 session (s) / week
Dark circles protocol
Several injections in dark circles
P R O T O C O L c o m b i n a t i o n
Needle
Injection
Use 30 G – 32 G
2 - 4 cc / point
Depth
Frequency
6 – 8 sessions for a complete treatment
Periorbital rejuvenation: Results
Dark circles around the eyes
*not actual patients of Dr. Izadi
Wrinkles of the lower eyelid
*not actual patients of Dr. Izadi
(Before) Skin elasticity improvement
*not actual patients of Dr. Izadi
(After) Skin elasticity improvement
*not actual patients of Dr. Izadi
Stretch marks improvement
4 – 6 sessions for a complete treatment
Time of treatment cure : 3 to 4 months
*not actual patients of Dr. Izadi
P R O T O C O L c o m b i n a t i o n
Needle
Injection
Use 30 G
2 cc / point (superficial S.M) 5 cc / point (deep S.M)
Depth
Frequency
1 mm (superficial S.M) 4 – 6 mm (deep S.M)
2 sessions / week
Scars improvement (Nach et al 2010)
Before
After
*not actual patients of Dr. Izadi
Scars 5 years after rhytidectomy procedure
4 – 6 sessions for a complete treatment
P R O T O C O L c o m b i n a t i o n
Needle
Injection
Use 30 G
2 cc / point (superficial Scars) 5 cc / point (deep Scars)
Depth
Frequency
1 mm (superficial Scars) 4 – 6 mm (deep Scars)
1 session / 2 weeks
Increase of the microcirculation and reorganization of the collagenous fibers improve scars
Cellulite improvement
Injections in square areas
12 sessions for a complete treatment
*not actual patients of Dr. Izadi
Before
After
P R O T O C O L c o m b i n a t i o n
Needle
Injection
Use 27 G - 30 G
2 cc / point (cutaneous relaxing) 5 cc/point (lipolysis)
Depth
Frequency
1 - 2 mm (cutaneous relaxing) 5 - 8 mm (lipolysis)
2 session / 1 weeks
Treatment of thighs localized adiposities (Brandi et al 2001)
50 cc/min, total 300 cc, 30G needle, 2 subcutaneous treatment per week during 3 weeks. Injections made anteriorly and posteriorly at the medium, medial, and lateral third of the thigh.
| Average of 48 women | Before | After |
|---|---|---|
| Thighs circumference (cm) | 56.1 | 54.2* (after the last session) |
| Knees circumference (cm) | 37.8 | 36.7* (after the last session) |
| Abdomen circumference (cm) | 78.4 | 75.7* (after the last session) |
| Laser Doppler values (PU) | 12.29 | 20.65* (after 30 min) |
| PO2 (mmHg) | 61.17 | 80.30* (after 30 min) |
* Statistically significant
Adipose tissue reduction and increase of microcirculation and O2
Subcutaneous tissue histology of the thighs before and after CO2 treatment (Brandi et al 2001)
Subcutaneous layers before treatment
Subcutaneous layers after treatment (3 weeks)
Detailed photography showing lysis of the adipocytes after treatment (3 weeks)
Carboxytherapy induces lipolysis of the adipocytes without involving the vascular structures.
Skin remodeling (Brandi et al 2001)
Before CO2 treatment
After CO2 treatment (3 weeks)
After treatment, the dermis presents a thicker appearance with the collagenous fibers distributed more diffusely (rearrangement)
Adipocytes cytometry of the abdominal wall (Costa et al 2011)
15 patients, 250 mL of CO2, 80 mL/min, 30G needle, 2 treatments per week during 6 weeks.
* Statistically significant
| Parameters | Before | After |
|---|---|---|
| Area (µm²) | 5349 | 56* |
| Perimeter (µm) | 268.82 | 188.5* |
| Length (µm) | 96.81 | 68.48* |
| Width (µm) | 71.5 | 46.3* |
| Number (in the sample)) | 449 | 300.13* |
| Ellipsity index (length/width) | 1.35 | 1.48 |
Adipose tissue reduction and increase of microcirculation and O2
Carboxytherapy effects on skin irregularity and its use as a complement to liposuction (Brandi et al 2004)
Group A (12 patients) : liposuction
Group B (12 patients) : 3 weeks after liposuction, 2 CO2 treatment per week during 10 weeks, 100 cc/min total 300 cc, 30G needle
Group C (18 patients) : CO2 therapy alone, 2 CO2 treatment per week during 10 weeks, 100 cc/min total 300 cc, 30G needle
| Time | Thigh circumference (avg in cm) | Knee circumference (avg in cm) | ||
|---|---|---|---|---|
| Liposuction | Liposuction + Carboxytherapy | Liposuction | Liposuction + Carboxytherapy | |
| Before surgery | 58.9 | 58.1 | 42.1 | 40.3 |
| After 3 weeks | 55 | 53 | 38 | 38 |
| After 2 months | 53.7 | 51.4 | 37.7 | 36.9 |
Carboxytherapy improves skin irregularity caused by the persistence of localized adiposities after liposuction.
Skin elasticity improvement (Brandi et al 2004)
| Time | Skin elasticity with a cutometer (average) |
|---|---|
| Before (Liposuction group) | 2.98 |
| After 2 months (Liposuction group) | 4.39* |
| Before (Liposuction + CO2 group) | 3.2 |
| After (Liposuction + CO2 group) | 4.92* |
| Before (CO2 group) | 2.88 |
| After 2 months (CO2 group) | 4.48* |
Carboxytherapy improves skin elasticity and is a good complement to liposuction
Carboxytherapy in the treatment of cellulite (Lee et al 2010)
57 women, 800 to 1000 cc for each thigh, 30G needle, 5 treatment sessions.
| 27 women (20-29 years old) | 18 women (30-39 years old) | 12 women (40-50 years old) | ||||
|---|---|---|---|---|---|---|
| Before | After last session | Before | After last session | Before | After last session | |
| Right thigh circumference (cm) | 55.1 | 53.6* | 54.3 | 53.2* | 58.2 | 56.6* |
| Left thigh circumference (cm) | 55.0 | 53.6* | 53.9 | 52.8* | 57.5 | 56.0* |
| Weight (kg) | 53.7 | 53.2 | 51.9 | 51.0* | 58.2 | 56.6* |
*statistically significant
Carboxytherapy decreases thigh circumference in the treatment of cellulite which leads to weight decrease.
Side effects and contraindications
Resolved within less than 1 hour:
- Pain
- Crepitus
Occasional side effects:
- Bruising / (Resolved within 7 to 10 days)
- Hemotoma
Contraindications: Phlebitis, cardiac/respiratory insufficiency, renal/hepatic insufficiency, severe arterial hypertension, pregnancy.
*not actual patients of Dr. Izadi
