DAXXIFY® Patient FAQs
ABOUT DAXXIFY®
DAXXIFY® is FDA approved to smooth moderate to severe lines between
the brows. It is the only long-lasting frown line treatment powered by a
peptide with results that last on average 6 months and up to 9 months
for some.*
The active ingredient in DAXXIFY® is a purified protein called botulinum
toxin type A.
Is your frown line treatment not lasting as long as you would like? If so,
DAXXIFY® could be the solution for you. Discuss your treatment goals
with your aesthetic services provider.
All frown line treatments require a special ingredient to stabilize
botulinum toxin A, the protein responsible for helping smooth moderate
to severe frown lines. For instance, BOTOX® Cosmetic uses human serum
albumin (HSA), a blood product, as its stabilizer. Dysport®, another frown
line treatment, uses HSA as a stabilizer and cow’s milk protein as a
protectant.
DAXXIFY® is unique because it is the only formulation that uses a novel peptide as a stabilizer and does not contain human or animal byproducts.
DAXXIFY® is unique because it is the only formulation that uses a novel peptide as a stabilizer and does not contain human or animal byproducts.
Peptides are both naturally occurring in live organisms and can also be
made synthetically in a lab.
Among the many functions of peptides, they can also comprise the building blocks of healthy collagen and elastin in your skin.
But they are manufactured and utilized in other products. Many people are aware of peptides in skincare products, where they may help the skin repair itself and slow down skin aging activity. And peptides are also used to stabilize other ingredients.
Among the many functions of peptides, they can also comprise the building blocks of healthy collagen and elastin in your skin.
But they are manufactured and utilized in other products. Many people are aware of peptides in skincare products, where they may help the skin repair itself and slow down skin aging activity. And peptides are also used to stabilize other ingredients.
The peptide in DAXXIFY® is synthetic, specifically created by Revance as
part of the neuromodulator’s innovative formulation.
DAXXIFY® is the only long-lasting frown line treatment powered by a
peptide. Results last on average 6 months and up to 9 months for
some.†
All frown line treatments require a special ingredient to stabilize botulinum toxin A, the protein responsible for helping smooth moderate to severe frown lines. For instance, BOTOX® Cosmetic uses human serum albumin (HSA), a blood product, as its stabilizer. Dysport®, another frown line treatment, uses HSA as a stabilizer and cow’s milk protein as a protectant.
DAXXIFY® is unique because it is the only formulation that uses a novel peptide as a stabilizer and does not contain human or animal byproducts.
All frown line treatments require a special ingredient to stabilize botulinum toxin A, the protein responsible for helping smooth moderate to severe frown lines. For instance, BOTOX® Cosmetic uses human serum albumin (HSA), a blood product, as its stabilizer. Dysport®, another frown line treatment, uses HSA as a stabilizer and cow’s milk protein as a protectant.
DAXXIFY® is unique because it is the only formulation that uses a novel peptide as a stabilizer and does not contain human or animal byproducts.
In short, no, and here’s why. Units are like fingerprints—they are a
proprietary measurement of a treatment’s unique potency.
Because of the differences in how treatments are formulated and
tested, you cannot compare or convert Units between them, just like
you cannot compare 2 fingerprints.
A clearer way to understand dosing is to look at how many nanograms of active ingredient (botulinum toxin type A) a product has.
A clearer way to understand dosing is to look at how many nanograms of active ingredient (botulinum toxin type A) a product has.
DAXXIFY®
Approved frown line dose: 40 Units
Amount of active ingredient: 0.18 nanograms
BOTOX® Cosmetic
Approved frown line dose: 20 Units
Amount of active ingredient: 0.18 nanograms
DYSPORT®
Approved frown line dose: 50 Units
Amount of active ingredient: 0.27 nanograms
As you can see, despite the number of Units, DAXXIFY® isn’t 2x the dose of BOTOX® Cosmetic, nor is Dysport® 2.5x the dose of BOTOX® Cosmetic. Talk to your provider about DAXXIFY® and your aesthetic goals.
Approved frown line dose: 40 Units
Amount of active ingredient: 0.18 nanograms
BOTOX® Cosmetic
Approved frown line dose: 20 Units
Amount of active ingredient: 0.18 nanograms
DYSPORT®
Approved frown line dose: 50 Units
Amount of active ingredient: 0.27 nanograms
As you can see, despite the number of Units, DAXXIFY® isn’t 2x the dose of BOTOX® Cosmetic, nor is Dysport® 2.5x the dose of BOTOX® Cosmetic. Talk to your provider about DAXXIFY® and your aesthetic goals.
DAXXIFY® is manufactured in California, and the only prescription frown
line treatment made in the United States. Conventional frown line
treatments are manufactured in other countries, then imported into the
United States.
In 2002, physicians and entrepreneurs founded a start-up in Silicon
Valley, California to explore the use of peptides in biologics for different
therapeutic uses. Their goal was to utilize peptides to transport
biologics, typically large molecules, through the skin.
The initial idea was to formulate botulinum toxin type A, the active ingredient in DAXXIFY®, with a peptide to see if it could be applied topically to the skin to treat crow’s feet wrinkles. Through this process, scientists discovered that the formulation was optimally administered through injection. Several clinical studies were created to determine the correct dose for an injectable product that would treat frown lines.
In clinical studies, DAXXIFY® lasted on average 6 months and up to 9 months for some people.‡ It is the only treatment of its kind formulated with a peptide.
The initial idea was to formulate botulinum toxin type A, the active ingredient in DAXXIFY®, with a peptide to see if it could be applied topically to the skin to treat crow’s feet wrinkles. Through this process, scientists discovered that the formulation was optimally administered through injection. Several clinical studies were created to determine the correct dose for an injectable product that would treat frown lines.
In clinical studies, DAXXIFY® lasted on average 6 months and up to 9 months for some people.‡ It is the only treatment of its kind formulated with a peptide.
SAFETY
DAXXIFY® was studied in the largest-ever clinical study for a frown line
treatment and included more than 2,800 people across different ages
and skin types. Here are some things you should know about DAXXIFY®:
- • There were no serious treatment-related side effects
- • The active ingredient in DAXXIFY® is botulinum toxin type A, an ingredient that has been used in frown line treatments for more than 20 years
- • 96% of people treated with DAXXIFY® were satisfied with their results§
The safety and efficacy of DAXXIFY® is well established, with more than
20 years of research. In fact, DAXXIFY® has been studied in the largest-
ever phase 3 clinical trial conducted for a frown line treatment and
included more than 2,800 people across different ages and with
different skin types. DAXXIFY® was studied in patients with varying skin
types.
No, not necessarily. The most common side effects observed in clinical
trials occurred within one to two weeks after injection and lasted only a
short while. This is consistent with other frown line treatments.
DAXXIFY® is well studied, with no serious treatment-related side effects
seen in large-scale clinical trials.
How should I prepare for my DAXXIFY® treatment?
Ask your aesthetic provider for pre-treatment instructions prior to your DAXXIFY® appointment.
A list of common avoidances before treatment include, but are not limited to:
• Retin-A
• Blood thinners
• Muscle relaxants
• Fish or oils rich in omega 3
• Allergy medication
• Topical steroids
• Sleep medications and supplements
• Aspirin
• St. John’s Wort
• Supplements
containing Vitamin E
• Ibuprofen
Ask your aesthetic provider for pre-treatment instructions prior to your DAXXIFY® appointment.
A list of common avoidances before treatment include, but are not limited to:
• Retin-A
• Blood thinners
• Muscle relaxants
• Fish or oils rich in omega 3
• Allergy medication
• Topical steroids
• Sleep medications and supplements
• Aspirin
• St. John’s Wort
• Supplements
containing Vitamin E
• Ibuprofen
DAXXIFY® injections are typically performed with a small needle and
people treated with frown line treatments say the injection feels like a
pinch.
If you are concerned about discomfort, talk to your injector about options for minimizing pain, such as icing the area or applying a topical numbing cream. Treatment with DAXXIFY® requires minimal downtime, and you can return to your daily routine immediately after your appointment.
There is a possibility that the area around the injection site will swell, turn red, and cause pain or tenderness from the injection itself; however, these side effects are typically very minor and go away after a few hours or days.
If you are concerned about discomfort, talk to your injector about options for minimizing pain, such as icing the area or applying a topical numbing cream. Treatment with DAXXIFY® requires minimal downtime, and you can return to your daily routine immediately after your appointment.
There is a possibility that the area around the injection site will swell, turn red, and cause pain or tenderness from the injection itself; however, these side effects are typically very minor and go away after a few hours or days.
If you’re like most people, you probably get a frown line treatment
around twice a year. But here’s the thing: conventional treatments only
last 3–4 months. If you are not able to get treated every 3-4 months,
that means you may spend the next 2-3 months of the year with those
frown lines staring back at you between treatments. That’s up to 4-6
months per year without optimal results!
DAXXIFY® is different. With those same 2 treatment visits, you can keep your frown lines smoother for a full year! ∥
DAXXIFY® is different. With those same 2 treatment visits, you can keep your frown lines smoother for a full year! ∥
You may see results with DAXXIFY® as early as the next day after
treatment, and typically within two days.
You may see results with DAXXIFY® as early as the next day after
treatment, and typically within two days. You should see noticeable
results within a two-week time frame. You may experience mild
injection-related bruising. In most cases, bruising heals within a few
days after injection.
ABOUT WRINKLES & INJECTABLE TREATMENTS
Several factors contribute to the formation of facial lines. Decreased
collagen production, cellular changes, genetics, environmental
damage, and sun damage may all play a role.
Facial lines are also formed by repeated muscle contractions such as frowning, squinting, or raising the eyebrows. These facial expressions cause the skin to furrow and fold, which eventually leads to the formation of wrinkles.
DAXXIFY® works below the skin’s surface to temporarily reduce the underlying muscle activity responsible for moderate to severe frown lines.
Facial lines are also formed by repeated muscle contractions such as frowning, squinting, or raising the eyebrows. These facial expressions cause the skin to furrow and fold, which eventually leads to the formation of wrinkles.
DAXXIFY® works below the skin’s surface to temporarily reduce the underlying muscle activity responsible for moderate to severe frown lines.
Botulinum toxins are biologics, produced from a bacterium called
Clostridium botulinum. They are used to inhibit the transmission of
specific chemical signals from nerves, primarily those signals that
cause muscular contractions. Botulinum toxin type A injections
temporarily relax the facial muscles that cause wrinkles between the
brows, reducing their appearance.
DAXXIFY® is the only FDA-approved, long-lasting frown line treatment (neuromodulator) that smooths moderate to severe lines between the brows, lasting an average of 6 months and up to 9 months in some.¶ Injections of specific botulinum toxin formulations are also utilized in the treatment of medical conditions.
DAXXIFY® is the only FDA-approved, long-lasting frown line treatment (neuromodulator) that smooths moderate to severe lines between the brows, lasting an average of 6 months and up to 9 months in some.¶ Injections of specific botulinum toxin formulations are also utilized in the treatment of medical conditions.
Injectable wrinkle treatments containing botulinum toxin type A have
been used to improve the look of moderate to severe frown lines for
more than 20 years. The first FDA-approved treatment was BOTOX®
Cosmetic, followed by Dysport®, Xeomin®, and Jeuveau®.
Although today’s wrinkle reducers all contain botulinum toxin type A, it’s important to know that no 2 treatments are alike and cannot be interchanged with each other.
Although today’s wrinkle reducers all contain botulinum toxin type A, it’s important to know that no 2 treatments are alike and cannot be interchanged with each other.
DAXXIFY® minimizes the appearance of moderate to severe frown lines
by temporarily relaxing the underlying muscles that cause these
wrinkles. DAXXIFY® is a long-lasting botulinum type A treatment with a
novel peptide.
Facial fillers, also known as dermal fillers, are typically made of hyaluronic acid and are used to add volume, fullness, and structure to areas of the face. They can help contour cheekbones, soften lines around the nose and mouth, and volumize lips. Dermal fillers target volume loss rather than muscle-related wrinkles.
Facial fillers, also known as dermal fillers, are typically made of hyaluronic acid and are used to add volume, fullness, and structure to areas of the face. They can help contour cheekbones, soften lines around the nose and mouth, and volumize lips. Dermal fillers target volume loss rather than muscle-related wrinkles.
