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Hormone Replacement Therapy for Men

What is What Is Testosterone Replacement Therapy (TRT)?

Restoring Vitality & Longevity

Testosterone Replacement Therapy (TRT) is a medical treatment designed to restore optimal testosterone levels in men experiencing low testosterone (Low T). As men age, testosterone levels naturally decline, leading to symptoms that impact energy, strength, cognition, and overall well-being. Endocrine disruptors are another reason to observe low level in younger subjects.

By restoring testosterone levels, TRT can help improve physical performance, mental clarity, libido, and metabolic health, ultimately enhancing longevity and quality of life.

How Testosterone Replacement Therapy Works

TRT Treatment Options

Testosterone can be administered in various forms, including:

  • Injectable Testosterone – Intramuscular or subcutaneous injections, usually administered weekly or biweekly.
  • Topical Gels & Creams – Applied daily to the skin for absorption.
  • Testosterone Pellets – Implanted under the skin for a steady hormone release over several months. I do not offer this version due to issues mentioned in the video. 
  • Oral & Nasal Testosterone – Newer formulations offering an alternative to injections and gels. Expensive

The right method depends on individual preferences, medical history, and physician recommendations.

What are the Benefits of Testosterone Replacement Therapy?

TRT offers numerous benefits for men suffering from Low T, including:

  • Increased Energy & Vitality – Enhanced stamina and endurance throughout the day.
  • Improved Muscle Mass & Strength – Supports lean muscle growth and fat reduction.
  • Better Cognitive Function – Improved focus, memory, and mental clarity.
  • Enhanced Libido & Sexual Function – Increased sex drive and improved erectile function.
  • Mood Stability & Well-Being – Reduction in anxiety, depression, and irritability.
  • Stronger Bones & Cardiovascular Health – Helps maintain bone density and supports heart health.

Scientific Evidence Supporting TRT Benefits

  1. Energy & Mood: Studies show that TRT can alleviate fatigue and improve mood in men with low testosterone levels (Zarrouf et al., 2009).
  2. Muscle & Fat Composition: Research indicates that TRT helps increase lean body mass and reduce fat mass (Bhasin et al., 2010).
  3. Cognitive Function: Some studies suggest a positive correlation between testosterone levels and cognitive performance, particularly in aging men (Cherrier et al., 2001).
  4. Bone Health: TRT has been shown to improve bone density, reducing the risk of osteoporosis (Snyder et al., 1999).
  5. Cardiovascular Health: While controversial, some research suggests TRT may improve cardiovascular health by reducing insulin resistance and inflammatory markers (Sharma et al., 2015).

More references in the endocrine disruptors video. 

What does Testosterone Replacement Therapy help with?

Symptoms of Low Testosterone (Low T)

Low testosterone levels can cause a range of symptoms, including:

✔️ Fatigue and decreased energy levels

✔️ Reduced muscle mass and strength

✔️ Increased body fat, particularly around the abdomen, specifically visceral fat which is an organ producing inflammatory cytokines

✔️ Brain fog and difficulty concentrating

✔️ Low libido and erectile dysfunction

✔️ Mood swings, irritability, or depression

✔️ Poor sleep quality

✔️ Reduced bone density

If you’re experiencing these symptoms, TRT may be a solution to restore hormonal balance.

For the best results, TRT should be combined with:

  • Proper Nutrition – A protein-rich, anti-inflammatory diet to support muscle and hormone balance.
  • Exercise – Strength training and cardiovascular workouts to optimize testosterone levels.
  • Sleep Optimization – 7–9 hours of quality sleep to enhance recovery and hormonal health.
  • Stress Management – Practices like meditation, deep breathing, and reducing chronic stress.

For younger patients there are other methods to increase testosterone level without prescribing hormones. Please watch the video for details. 

Is TRT Safe?

When prescribed and monitored by a knowledgeable healthcare provider, TRT is generally safe and effective. Regular follow-ups and lab monitoring are essential to assess hormone levels, hematocrit, PSA, and other biomarkers to ensure optimal health and minimize risks.

Who is a good candidate for TRT?

TRT is ideal for men with clinically low testosterone levels, confirmed through lab testing, and experiencing symptoms affecting their quality of life.

An evaluation should include:

✔️ Comprehensive hormone panel

✔️ Medical history review

✔️ Lifestyle and metabolic assessment

Take control of your health.

If you’re experiencing symptoms of Low T, a personalized TRT plan may help you regain energy, vitality, and longevity. Schedule a consultation today to learn how hormone optimization can enhance your well-being.

Contact us today for an appointment

Why Choose Pristine Wellness?

At Pristine Wellness Center, Dr. Izadi, our esteemed medical director, personally performs every procedure. As one of the most experienced medical professionals working with these procedures, she has achieved a remarkably high success rate, as reflected in her patients’ glowing testimonials.

Dr. Izadi is a quadruple board-certified physician with extensive expertise in functional and integrative medicine. She continuously enhances her knowledge by traveling the world, learning from leading doctors and scientists, and bringing the most advanced techniques back to her patients.

At Pristine Wellness Center, we pride ourselves on offering highly personalized care in a concierge-style setting—all at an affordable price, making top-tier treatments accessible to the average American.

Experience the difference in care and expertise at Pristine Wellness Center.

Risks & References about Testosterone Replacement Therapy

Risks & Possible Side Effects
  •   Increased Red Blood Cell Count: TRT can raise hematocrit, which may increase the risk of blood clots (Coviello et al., 2008).
  •   Fluid Retention: Some men may experience mild swelling, especially at the beginning of therapy.
  •   Acne or Skin Irritation: Increased oil production can lead to acne or skin reactions.
  •   Prostate Health Concerns: TRT does not appear to increase prostate cancer risk in most men, but monitoring PSA levels is recommended (Morgentaler et al., 2015).

A tailored approach to TRT, combined with lifestyle optimization, can significantly reduce these risks.

  • Bhasin, S., et al. (2010). Effects of Testosterone Supplementation on Body Composition, Muscle Strength, and Physical Function in Older Men. Journal of Clinical Endocrinology & Metabolism, 95(2), 639–650.
  • Cherrier, M. M., et al. (2001). Cognitive Effects of Short-Term Manipulation of Serum Testosterone Levels in Healthy Young Men. Journal of Clinical Endocrinology & Metabolism, 86(10), 5127–5135.
  • Coviello, A. D., et al. (2008). Effects of Graded Doses of Testosterone on Erythropoiesis in Healthy Young and Older Men. Journal of Clinical Endocrinology & Metabolism, 93(3), 914–919.
  • Morgentaler, A., et al. (2015). Testosterone Therapy and Prostate Cancer: A Historical Perspective on a Modern Myth. European Urology, 67(1), 44–52.
  • Sharma, R., et al. (2015). Testosterone Replacement Therapy in Hypogonadal Men and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis. American Journal of Medicine, 128(3), 261–274.
  • Snyder, P. J., et al. (1999). Effect of Testosterone Treatment on Bone Density in Men Over 65 Years of Age. Journal of Clinical Endocrinology & Metabolism, 84(6), 1966–1972.
  • Zarrouf, F. A., et al. (2009). Testosterone and Depression: Systematic Review and Meta-Analysis. Journal of Psychiatric Practice, 15(5), 289–305.